1H-Isoindol-1-one, 2,3-dihydro-5-hydroxy-3-[2-[[[[1-[(1-methyl-1H-imidazol-4-yl)methyl]-1H-indol-6-yl]methyl]amino]methyl]-1H-indol-3-yl]-, (3S)-
BI-2852
CAS: 2375482-51-0
Molecular Formula: C31H28N6O2
1H-Isoindol-1-one, 2,3-dihydro-5-hydroxy-3-[2-[[[[1-[(1-methyl-1H-imidazol-4-yl)methyl]-1H-indol-6-yl]methyl]amino]methyl]-1H-indol-3-yl]-, (3S)- - Names and Identifiers
1H-Isoindol-1-one, 2,3-dihydro-5-hydroxy-3-[2-[[[[1-[(1-methyl-1H-imidazol-4-yl)methyl]-1H-indol-6-yl]methyl]amino]methyl]-1H-indol-3-yl]-, (3S)- - Physico-chemical Properties
| Molecular Formula | C31H28N6O2 |
| Molar Mass | 516.59 |
| Density | 1.41±0.1 g/cm3(Predicted) |
| Boling Point | 906.5±65.0 °C(Predicted) |
| pKa | 8.95±0.40(Predicted) |
| Storage Condition | 2-8°C，惰性气体保存 |
| In vitro study | BI-2852 (Compound 1) (10 nM-10 µM; 2 hours) shows a dose-dependent pERK modulation and antiproliferative effect at EC 50 s of 5.8 µM and 6.7 µM in soft agar and low serum conditions in NCI-H358 cells. |
1H-Isoindol-1-one, 2,3-dihydro-5-hydroxy-3-[2-[[[[1-[(1-methyl-1H-imidazol-4-yl)methyl]-1H-indol-6-yl]methyl]amino]methyl]-1H-indol-3-yl]-, (3S)- - Reference Information
| biological activity | BI-2852 is a switch SI/II pocket KRAS inhibitor designed based on drug structure, it has nanomolar affinity through structure-based drug design. BI-2852 is mechanistically different from covalent KRAS G12C inhibitors (binding to switch II), binding to active KRAS g12d is 10-fold stronger than KRAS wt (740 nM vs 7.5 μm). BI-2852 blocking the interaction of GEF,GAP, and effector with KRAS leads to inhibition of downstream signaling and antiproliferative effects in KRAS mutant cells. |
Last Update：2024-04-09 19:05:17
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tech@medchemexpress.com
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Product Name: BI-2852 Visit Supplier Webpage Request for quotationCAS: 2375482-51-0
Tel: +86-400-900-4166
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Mobile: +86-18621343501
QQ: 2881950922
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View History
1H-Isoindol-1-one, 2,3-dihydro-5-hydroxy-3-[2-[[[[1-[(1-methyl-1H-imidazol-4-yl)methyl]-1H-indol-6-yl]methyl]amino]methyl]-1H-indol-3-yl]-, (3S)-
Toluene-d6 2,4-Diisocyanate
4-Methoxyoxalyl-3-oxopiperidine-1-carboxylic acid tert-butyl ester
1-[2-(二甲氨基)乙基]-2,3-二氢-1H-吲哚-2,3-二酮
2-铝-甲基苯甲腈
乙二酸二丙-2-烯酯
磷酸二氢钠单水合物
2,5-二氯-7-甲氧基喹唑啉-4-酮
CHEMBRDG-BB 9004221
Toluene-d6 2,4-Diisocyanate
4-Methoxyoxalyl-3-oxopiperidine-1-carboxylic acid tert-butyl ester
1-[2-(二甲氨基)乙基]-2,3-二氢-1H-吲哚-2,3-二酮
2-铝-甲基苯甲腈
乙二酸二丙-2-烯酯
磷酸二氢钠单水合物
2,5-二氯-7-甲氧基喹唑啉-4-酮
CHEMBRDG-BB 9004221